![]() This is a 2020 ARVO Annual Meeting abstract. AS-OCT is a useful tool to systematically imaging the ocular surface and anterior segment, allowing the detection of all corneal layers from front to back with sufficient details to make quantitative analyses. The understanding of the cascade of events involved in rhNGF-driven corneal wound healing process and a better knowledge of how this process influences corneal biomechanics are essential to improving outcomes of treatments. Los otorrinos más recomendados de Rosario: consultá opiniones, comprobá su disponibilidad y pedí turno online en segundos. Second, the scar tissue eventually cleared on slit-lamp examination. It had a high signal on AS-OCT, displaying a different appearance from that of the normal corneal stroma. The scar tissue appeared opaque, as seen with the slit-lamp. A larger ulcer area was associated with a greater increase in CT (p<0.01). In eyes affected by NCU, AS-OCT scans revealed an average CT in the thinnest point of 276,3μm (☗4,12) before treatment with an average increase in CT (Δp) of 176,5μm (☖0,3) at the end of the treatment (week8). In all PED, the stromal thickness was preserved, an augmented reflectivity of the anterior stroma was detected, 3 (60%) eyes experienced epithelial hyperplasia regressed in the following months. At the end of the treatment: the average re-epithelialization time was 3.9☐,5 weeks. AS-OCT scans in PED showed interruption of the epithelial layer without thinning of the corneal stroma. The mean aesthesiometry detected was 1.3☐.5cm. Five eyes (31.3%) experienced persistent epithelial defect(PED), and 11 eyes (68.7%) had a neurotrophic corneal ulcer(NCU). The mean patients’ age was 60.9 (☒1.1) years, and 11 (68.7%) were females. We compared AS-OCT images with the findings from the slit-lamp examination.ĭata from 16 eyes were included. Several AS-OCT (pachymetric mapping, raster-scan and line-mode) centered on the area of the minimum corneal thickness(CT) were performed. Corneal sensation was evaluated at first consultation and follow-ups. All patients underwent slit-lamp biomicroscopy examination plus fluorescein staining. ![]() Our study aims to evaluate anterior segment optical coherence tomography (AS-OCT) to detect wound healing process as per monitoring the efficacy of cenegermin in the treatment of moderate-to-severe neurotrophic keratitis.Ī retrospective chart review was performed to identify patients treated with cenegermin at Clinica Oculistica, University of Genoa, Italy since May 2018.
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